THE SANCO TEST IS ALSO AVAILABLE FOR:
CONTRAINDICATIONS FOR SANCO:
We do not perform the testing in case of:
1. Pregnancy under 10 weeks
2. Diagnosed cancer
3. Organ / bone marrow transplantation
4. Blood transfusion in the last 3 months
5. Death of one fetus in a multiple pregnancy after week 8
6. Receiving father’s lymphocytes or stem cells therapy
7. Lupus erythematosus (SLE)
Indications for consultation of a specialist in case of:
1. some types of congenital fetal defects detected in the uUltrasound
2. high risk of trisomy after the composite test (colloquially the PAPP-A test)
Indications for consultation of SANCO helpdesk if:
1. You’ve been through a miscarriage of one fetus in multiple pregnancy
2. You’ve been diagnosed with aneuploidy, translocation, deletion or chromosomal microduplication, also in the form of mosaicism
3. You are a recipient of a father’s lymphocytes.
4. You are in the course of immunotherapy
CURRENT RECOMMENDATIONS
American College of Obstetricians and Gynecologists/Society for Maternal-Fetal Medicine, ACOG/SMFM and American College of Medical Genetics and Genomics (ACMG) and Polish recommendations:
| Polish recommendations1 | ACOG/SMFM2 | ACMG3 | |
|---|---|---|---|
| Recommended sampling time (gestational age) | From the 10th to the 15th week of the pregnancy | From the 10th week of the pregnancy | From the 10th week of the pregnancy |
| For whom NIPT screening for the most common aneuploidies (T21, T18, T13) | Intermediate risk population (1:100- 1:1000) after the first trimester combined screening | Whole population | High, low and intermediate risk populations |
| Screening for sex chromosomes aneuploidies | No position | YES | YES |
| Microdeletions and other trisomies | No position | NOT RECOMMENDED | NOT RECOMMENDED, but patients should be informed about the availability of the extended possibilities |
1. Recommendations of the Panel of Experts of the Polish Society of Gynecologists and Obstetricians (former Polish Gynaecological Society) and the Polish Society of Human Genetics on prenatal genetic screening performed on cell-free fetal DNA. Ginekol Pol., 2015, 86, 966-969
2. Gregg AR, Skotko BG, Benkendorf JL, et al. Noninvasive prenatal screening for fetal aneuploidy, 2016 update: a position statement of the American College of Medical Genetics and Genomics. Genet Med. 2016;18(10):1056-1065.
3. Gregg AR, Skotko BG, Benkendorf JL, et al. Noninvasive prenatal screening for fetal aneuploidy, 2016 update: a position statement of the American College of Medical Genetics and Genomics. Genet Med. 2016;18(10):1056-1065.