We don’t recommend to perform the SANCO Test within 12 months after a blood transfusion, after bone marrow or organ transplantation, after stem cell therapy, immediately after vaccination with partner lymphocytes and before 8 weeks from fetal death in a multiple pregnancy, on condition that death occurred no later than at 8th week of pregnancy. Most chromosomal aberrations in a pregnant woman are also a contraindication to the SANCO testing and each case should be reported to the physician. It has been observed that certain diseases of the immune and hematopoietic system make it difficult to obtain the test result. Sometimes, also for reasons other than those indicated above, the SANCO Test is not the right choice. That is why we recommend consultation each time before performing the test.